logo

Please enter a search term to begin your search.

Photochemistry and Spectroscopy Department

Institute of Physical Chemistry, Polish Academy of Sciences

Patrycja Kowalska – Research Fellow

Office no.: 200

Phone number: 3228

 

Education

Nov. 2002 - Jan. 2008

Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw; Ph.D. Thesis titled "Application of circular dichroism spectroscopy for structural research of bicyclic betalactam carba- and oxaderivatives" under the supervision of Prof. Jadwiga Frelek

Oct. 1997 - Jun. 2002 

University of Bialystok, Department of Chemistry; M. Sc. Thesis titled "Synthesis of secondary amines” under the supervision of Dr hab. Janusz Poplawski

Work Experience

February 2012 – present

Research Fellow in Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Prof. J. Waluk group; Magnetic Circular Dichroism, porphycenes, porphyrins, metal nanoparticles.

June 2011 – Aug. 2011

Postdoctoral position in University of Warwick, UK; funded by Institute of Advanced Studies, Prof. A. Rodger group; “Development of the new orientation methods for Raman Linear Difference (RLD) spectroscopy.”

May 2009 - May 2011

Postdoctoral position in University of Warwick, UK; funded by a Marie Curie Fellowship, Prof. A. Rodger group; “Flow-aligned polarised Raman of biomacromolecular entities”

Jan. 2008 - May 2009

Research fellow in Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Prof. J. Frelek group; “Synthesis and chiroptical properties of β-lactam antibiotic derivatives”

 

Publications

1. Kowalska, P.; Gawinkowski, S.; Sarma, T.; Panda, P. K.; Waluk, J. J.Phys.Chem. A, 2014118, 1038-1046

2. Ostapko, J.;  BuczyƄska, J.; Pszona, M.; Kowalska, P.; Waluk, J. J. Porphyrins Phthalocyanines, 2014, 18, 686-697

3. Kowalska, P.; Cheeseman, J. R.; Razmkah, K., Green, B.; Nafie, L., Rodger, A., Anal. Chem., 2012, 84 (3), 1394–1401

4. Woznica, M.; Butkiewicz, A.; Grzywacz, A.; Kowalska, P.; Masnyk, M.; Michalak, K.; Luboradzki, R.; Furche, F.; Kruse, H.; Grimme, S.; Frelek, J.; J. Org. Chem., 2011, 76 (9), 3306–3319

5. Woznica, M.; Kowalska, P.; Lysek, R.; Masnyk, M.; Gorecki, M.; Furche, F.; Frelek, J., Current Organic Chemistry 2010, 14, 1022-1036.

6. Chmielewski, M.; Cierpucha, M.; Kowalska, P.; Kwit, M.; Frelek, J., Chirality 2008, 20, 621-627.

7. Gomez, E.; D., Frelek, J.; Woznica, M.; Kowalska, P.; Jazwinski, J.; Duddeck, H., Heterocycles 2007, 74, 357-367.

8. Frelek, J.; Kowalska, P.; Masnyk, M.; Kazimierski, A.; Korda, A.; Woznica, M.; Chmielewski, M.; Furche, F., Chemistry – A European Journal 2007, 13 (23), 6732-6744.

9. Danh, T. T.; Bocian, W., Kozerski; L., Szczukiewicz, P.; Frelek, J.; Chmielewski, M., Eur. J. Org. Chem. 2005, 429-440.

10. Borsuk, K.; Grzeszczyk, B.; Szczukiewicz, P.; Przykorska, B.; Frelek, J.; Chmielewski, M., Chirality 2004, 16, 414-421.

11. Cierpucha, M.; Solecka, J.; Frelek, J.; Szczukiewicz, P.; Chmielewski, M., Biorg. Med. Chem. 2004, 12, 405-416.

 

 

Research interests

My research obeys spectroscopy methods such as UV/Vis, Circular Dichroism (CD) and Magnetic Circular Dichroism (MCD). My present studies are focused on interactions between noble metal nanoparticles and chromophoric systems such as porphyrins and porphycenes. I am also interested in the electronic structure as well as redox processes occurring within mentioned chromophores. The main tool I am using in my research is MCD technique.

 

MAGNETIC CIRCULAR DICHROISM

 

MCD basics:

-          the presence of  magnetic field causes the different absorption of RCP and LCP, what introduces the chirality into the achiral compound; therefore the investigated molecule doesn’t need to be chiral,

-          MCD spectrum is richer compare to ordinary absorption curve, but still it is a superposition of all contributions,

-          MCD signal is proportional to the strength of magnetic field,

-          only that component of magnetic field, which is parallel to the light propagation direction contributes to the MCD effect,

-          observed MCD spectrum is Δε/ε ratio.

 

 

MCD vs absorption

 

 

My expertise obeys not only mentioned techniques. During my postdoc I worked on development of flow-aligned polarised Raman (FAPR) of biomacromolecular entities. My goal was to develop a new form of spectroscopy: FAPR that will greatly enhance our ability to obtain structural information on a range of molecules including DNA and membrane proteins. Most of the work was focused on small molecules (steroids, nucleotides and riboflavin derivatives) aligned in PE films. A universal Couette flow cell has been designed and the first experiments with liquid samples have been performed. Finally the new method was called Raman linear difference spectroscopy (RLD). [Anal. Chem. 2012, 84 (3), 1394–1401]

My PhD was concerned with an application of circular dichroism (CD) spectroscopy to structural studies of bicyclic β-lactam carba- and oxaderivatives to establish the scope and limitation of a newly introduced helicity rule. The project included CD, conformational analysis (CaChe software), TD DFT (time-dependent density functional theory) modelling of theoretical curves (Gaussian 03W). Despite its spectroscopic aspects, my PhD predominantly was built around synthetic chemistry using radical methods and metathesis reaction for synthesis of bicyclic β-lactam antibiotics.[Chemistry – A European Journal 2007, 13 (23), 6732-6744]