Rapid detection and identification of bacterial meningitis pathogens in ex vivo clinical samples by SERS method and principal component analysis

Kamińska, A.; Witkowska, E.; Kowalska, A.; Skoczyńska, A.; Ronkiewicz, P.; Szymborski, T.; Waluk, J. Anal. Methods 2016, 8, 4521-4529.

High-efficient SERS-based detection of cerebrospinal fluid neopterin as a diagnostic marker of bacterial infection

Kamińska, A.; Witkowska, E.; Kowalska, A.; Skoczyńska, A.; Gawryszewska, I.; Guziewicz, E.; Snigurenko, D.; Waluk, J. Anal. Bioanal. Chem., 2016, 408, 4319-4327.

ZnO oxide films for ultrasensitive, rapid, and label-free detection of neopterin by surface-enhanced Raman spectroscopy

Kamińska, A.; Kowalska, A. A.;  Snigurenko, D.;  Guziewicz, E.; Lewiński, J.; Waluk, J. Analyst 2015, 140, 5090-5098.

 

 

 

Neopterin (2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-one) is a marker of cellular immune system activation. Using SERS, we are able to detect neopterin at low concentration in blood plasma and bacteria-infected cerebrospinal fluid. In these studies, three meningitis pathogens, namely, Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae were detected and identified simultaneously using a label-free SERS method.