Photochemistry and Spectroscopy Department

Institute of Physical Chemistry, Polish Academy of Sciences

Rapid detection and identification of bacterial meningitis pathogens in ex vivo clinical samples by SERS method and principal component analysis

Kamińska, A.; Witkowska, E.; Kowalska, A.; Skoczyńska, A.; Ronkiewicz, P.; Szymborski, T.; Waluk, J. Anal. Methods 2016, 8, 4521-4529.

High-efficient SERS-based detection of cerebrospinal fluid neopterin as a diagnostic marker of bacterial infection

Kamińska, A.; Witkowska, E.; Kowalska, A.; Skoczyńska, A.; Gawryszewska, I.; Guziewicz, E.; Snigurenko, D.; Waluk, J. Anal. Bioanal. Chem., 2016, 408, 4319-4327.

ZnO oxide films for ultrasensitive, rapid, and label-free detection of neopterin by surface-enhanced Raman spectroscopy

Kamińska, A.; Kowalska, A. A.;  Snigurenko, D.;  Guziewicz, E.; Lewiński, J.; Waluk, J. Analyst 2015, 140, 5090-5098.




Neopterin (2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-one) is a marker of cellular immune system activation. Using SERS, we are able to detect neopterin at low concentration in blood plasma and bacteria-infected cerebrospinal fluid. In these studies, three meningitis pathogens, namely, Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae were detected and identified simultaneously using a label-free SERS method.